BioG 1105-1106 at Cornell University
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Unit 1: Demos

Objective 3:

Can You Make DNA? Play the Double Helix game and find out!
Cornell researchers 'unzip' molecules (optional)

Objective 4:

Does DNA have an overall charge?

Objective 6:

How is DNA replicated?
Leading Strand Replication animation
DNA Replication Review animation

Objective 10:

Okazaki fragments
Synthesis of the Lagging Strand animation

Objective 15:

Can you control the cell cycle?  Play the Cell Cycle game and find out!
Cell cycle clock and cancer
Cell surface changes during the cell cycle

Objective 16:

Centromere Sequence (16c)

Objective 17:

3 ways eukaryotic and prokaryotic chromosomes differ (17b)

Objective 18:

Slides

Objective 23:

Asexual reproduction
Sexual reproduction

Objective 24:

Slides - oogenesis in Ascaris
New use for polar bodies (optional)

Objective 25:

Slides - stages of meiosis / mitosis

Does DNA have an overall charge?

To answer this question, think about the structure of the nucleotides, their charge, and how the nucleotides are joined to an existing DNA chain.

Recall that the DNA chains are always synthesized in the 5' ––> 3' direction on the DNA template, and that the deoxynucleotides are joined through condensation reactions only to the 3'–OH end of the chain. The phosphate group will retain its negative charge, and thus DNA is negatively charged.

The bond that forms between the nucleotide being added and the pre-existing chain is called a phosphodiester bond and is a strong covalent bond.

© BIOG 1105-1106